Professor Mieyal has been a featured speaker at many international symposia on Redox Regulation and Thiol Homeostasis in recent years, including those sponsored by the American Society of Biochemistry and Molecular Biology, the International Redox Network, and the International Gordon Conferences. Mieyal is recognized internationally for advancing knowledge of redox regulation and signal transduction in health and disease, especially involving the glutaredoxin and thioredoxin enzyme systems. Mieyal’s laboratory is focused on mechanisms of alterations in redox regulation in Parkinson’s disease and cardiovascular diseases, both prevalent among the elderly.ĭr. Stokes Veterans Affairs Medical Research Center. Current research emphasis in Dr. Mieyal is Professor and Vice-Chairman of the Department of Pharmacology where he conducts his research program and oversees the educational mission of the Department. He holds joint appointments in the departments of Chemistry and Environmental Health Sciences, and in the Comprehensive Cancer Center. He also holds a Research Chemist appointment at the Louis B. Mieyal did postdoctoral research studies at Brandeis University, and he began his independent academic career at Northwestern University with a joint appointment in the Departments of Pharmacology and Biochemistry.ĭr. degree in Biochemistry from Case Western Reserve University. Dr. degree in Chemistry from John Carroll University. He earned his Ph.D. Is this an evidenced based conclusion, or is it a clever marketing ploy? Are ROS necessary for natural functions in the body, or should they be destroyed at all costs? A critical look at historical and modern research on the role of ROS in health and disease provides a perspective on the effective use of antioxidants.ĪNTIOXIDANTS - A path to immortality or a ride to the grave:ĭr. Accordingly, society has embraced the notion that antioxidants are crucial to a healthy longevity.

) have been attributed to ROS being out of control. The diseases of the elderly (Alzheimer’s disease, Parkinson’s disease, cardiovascular disease, etc. We have learned of correlations between ROS-mediated toxicity and aging. (Professors of Pharmacology at Case Western Reserve University)Īre antioxidants the key to health and longevity, or a risk to normal body functions? From the ancient time about 3 billion years ago when oxygen became a major component of our atmosphere, organisms from bacteria to humans have had to adapt to so-called “reactive oxygen species” (ROS) with defense mechanisms to avoid damage to vital cellular functions. Antioxidants - Direct from the Fountain of Youth?Īre antioxidants the magic elixir of immortality or poisons in disguise?

G elixir of immortality